个人简介

贾焱，博士，教授，博士生导师，北京市属高校青年拔尖人才，北京工商大学化学与材料工程学院副院长，北京市党外高级知识分子联谊会理事。美国罗格斯，新泽西州立大学访问学者。在British Journal of Dermatology、Journal of Cosmetic Dermatology等化妆品、皮肤学领域权威学术期刊发表论文40余篇，授权国家发明专利6件。主持国家自然科学基金、北京市属高校青年拔尖人才项目、北京工商大学优秀青年项目、北京市教委科研计划面上项目等。主持企事业单位委托项目20余项。

联系方式：E-mail: jiayan@btbu.edu.cn；Tel: 010-68985362

二 研究方向

主要从事精准护肤与皮肤健康体系研究，以皮肤问题为导向，基于生命科学、皮肤科学、药剂学等新兴技术，开发针对不同皮肤类型人群的化妆品。

三 社会兼职

北京市党外高级知识分子联谊会 理事

美中化妆品专业委员会（CACPA） 会员

北京中西医结合学会环境与健康专业委员会 委员

Frontiers in Sustainable Food Systems杂志 编委

Journal of Dermatological Science、Journal of Cosmetic Dermatology等学术期刊审稿人

四 代表性研究课题（项目）情况

[1] 主持国家自然科学基金，项目名称：纳豆激酶分子内分子伴侣与成熟肽断裂的分子机理研究，项目号：31501415.

[2] 主持北京市属高校青年拔尖人才项目，项目号：CIT&TCD201804027.

[3] 主持北京市教委科研计划面上项目，项目名称：中国男性雄激素性脱发的病因研究与头皮脂质成分分析，项目号：SQKM201610011008.

[4] 主持北京工商大学学位与研究生教育改革项目，项目名称：适用于我校化妆品科学与技术专业的轮转导师制研究.

[5] 主持企事业单位委托课题，项目名称：XX系列化妆品的开发.

[6] 主持企事业单位委托课题，项目名称：XX化妆品对皮肤脂质组的影响及机制研究

[7] 主持企事业单位委托课题，项目名称：基于质谱技术的皮肤脂质成分分析.

[8] 主持企事业单位委托课题，项目名称：皮肤角质管理策略研究.

[9] 主持企事业单位委托课题，项目名称：XX面膜中荧光剂的含量分析.

[10] 主持企事业单位委托课题，项目名称：化妆品生产配方、工艺、标准情况调研

五 代表性论文

[1] Mingyue Zhou, Hecong Wang, Manli Yang, Ming Yang, Ying Gao, Yan Jia*. Lipidomic analysis of facial skin surface lipids reveals an altered lipid profile in infant acne. British Journal of Dermatology, 2020, 182(3): 817-818.

[2] Mingyue Zhou#, Yao Gan#, Congfen He, Zhou Chen, Yan Jia*. Lipidomics reveals skin surface lipid abnormity in male youth acne. British Journal of Dermatology. 2018. 179(3):732-740.

[3] Manli Yang, Jingyu Wu, Qingrong Huang, Yan Jia*. Probing the role of catalytic triad on the cleavage between intramolecular chaperone and NK mature peptide. Journal of Agricultural and Food Chemistry. 2021, 69(7): 2348-2353.

[4] Manli Yang, Mingyue Zhou, Yuan Li, Hong Huang, Yan Jia*. Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness. Scientific Reports. 2021, 2(11): 3229.

[5] Yan Jia*, Yao Gan, Congfen He, Zhou Chen, Cheng Zhou. The mechanism of skin lipids influencing skin status. Journal of Dermatological Science. 2018, 89(2):112-119.

[6] Yan Jia*, Mingyue Zhou, Hong Huang, Yao Gan, Manli Yang, Ruiheng Ding. Characterization of circadian human facial surface lipid composition. Experimental Dermatology. 2019, 28(7): 858-862.

[7] Mingyue Zhou, Manli Yang, Yumei Zheng, Kun Dong, Liya Song, Congfen He, Wei Liu, Yiyu Wang, Yan Jia*. Skin surface lipidomics revealed the correlation between lipidomic profile and grade in adolescent acne. Journal of Cosmetic Dermatology, 2020, 19(12): 3349-3356.

[8] Mingyue Zhou, Yao Gan, Manli Yang, Congfen He, Yan Jia*. Lipidomics analysis of facial skin surface lipids between forehead and cheek: Association between lipidome, TEWL, and pH. Journal of Cosmetic Dermatology, 2020, 19(10): 2752-2758.

[9] Le Cui, Congfen He, Linna Fan, Yan Jia*. Application of lipidomics to reveal differences in facial skin surface lipids between males and females. Journal of Cosmetic Dermatology. 2018. doi: 10.1111/jocd.12474.

[10] Xinchao Li, Congfen He, Zhou Chen, Cheng Zhou, Yao Gan, Yan Jia*. A review of the role of sebum in the mechanism of acne pathogenesis. Journal of Cosmetic Dermatology. 2017, 16(2):168-173.

[11] Xinchao Li, Congfen He, Liya Song, Ting Li, Shumei Cui, Liping Zhang, Yan Jia*. Antimicrobial activity and mechanism of Larch bark procyanidins against Staphylococcus aureus. Acta Biochimica et Biophysica Sinica. 2017, 49(12):1058-1066.

[12] Manli Yang, Mingyue Zhou, Hecong Wang, Ming Yang, Ying Gao, Yan Jia*. Lipidomics reveals the role of glycoceramide and phosphatidylethanolamine in infantile acne. Journal of Cosmetic Dermatology. 2021, 20(3): 947-954.

[13] Linna Fan, Congfen He, Ligang Jiang, Yongxian Bi, Yinmao Dong, Yan Jia*. Brief analysis of causes of sensitive skin and advances in evaluation of anti-allergic activity of cosmetic products. International Journal of Cosmetic Science. 2016, 38(2):120-127.

[14] Yan Jia*, Yingjie Sun, Congfen He, Shuangyan Tang, Enguang Zhu. Research progress on the mechanism of intramolecular chaperone. Progress in Biochemistry & Biophysics. 2016, 43(5):443-448.

[15] Yan Jia, Xinhua Cao, Yu Deng, Wei Bao, Changyan Tang, Hanjing Ding, Zhongliang Zheng, Guolin Zou. Four residues of propeptide are essential for precursor folding of nattokinase. Acta Biochimica et Biophysica Sinica. 2014, 46(11):957-964.

[16] Yan Jia, Hui Liu, Wei Bao, Meizhi Weng, Wei Chen, Yongjun Cai, Zhongliang Zheng, Guolin Zou. Functional analysis of propeptide as an intramolecular chaperonefor in vivo folding of subtilisin nattokinase. FEBS Letters. 2010, 584(23):4789-4796.

[17] Linna Fan, Yan Jia, Le Cui, Xinchao Li, Congfen He*. Analysis of sensitive skin barrier function: basic indicators and sebum composition. International Journal of Cosmetic Science. 2018, 40(2):117-126.

[18] Chaoning Liang, Yi Zhang, Yan Jia, Wenzhao Wang, Youhai Li, Shikun Lu, Jianming Jin*, Shuangyan Tang*. Engineering a Carbohydrate-processing Transglycosidase into Glycosyltransferase for Natural Product Glycodiversification. Scientific Reports. 2016, 6:21051.

[19] Le Cui, Yan Jia, Zhiwei Cheng, Ying Gao, Gaolei Zhang, Jingyi Li, Congfen He*. Advancements in the maintenance of skin barrier/skin lipid composition and the involvement of metabolic enzymes. Journal of Cosmetic Dermatology. 2016, 15(4):549-558.

[20] Hua Cheng, Yan Jia, Ling Wang, Xiaoying Liu, Guangrong Liu, Li Li, Congfen He*. Isolation and structural elucidation of a novel homogenouspolysaccharide from Tricholoma matsutake. Natural Product Research. 2016, 30(1):58-64.

[21] Meizhi Weng, Xiongwei Deng, Wei Bao, Li Zhu, Jieyuan Wu, Yongjun Cai, Yan Jia, Zhongliang Zheng, Guolin Zou*. Improving the Activity of the Subtilisin Nattokinase by Site-directed Mutagenesis and Molecular Dynamics Simulation. Biochemical and Biophysical Research Communications. 2015, 465:580-586.

[22] Hanjing Ding, Hui Liu, Yan Yin, Ying Ding, Yan Jia, Qingming Chen, Guolin Zou*. Zhongliang Zheng. Insights into the modulation of optimum pH by a single histidine residue in arginine deiminase from Pseudomonas aeruginosa. Biological Chemistry. 2012, 393(9):1013-1024.

[23] Yongjun Cai, Wei Bao, Shujun Jiang, Yan Jia, Zhongliang Zheng, Guolin Zou*. Directed evolution improves the fibrinolytic activity of nattokinase from Bacillus natto. FEMS microbiology letters. 2011, 325(2):155-161.

[24] 甘瑶, 何聪芬, 贺可可, 李欣超, 贾焱*. 基于脂质组学的青年女性早晚面部皮肤表面脂质差异分析. 日用化学工业. 2018, 48(3):151-161.

[25] 崔乐, 贾焱, 成志伟, 高莹, 张高磊, 李靖怡, 何聪芬*. 维持皮肤屏障研究进展--脂质的分泌及组成. 中国皮肤性病学杂志. 2016, (6):640-643.

[26] 崔乐, 高莹, 张高磊, 贾焱, 李靖怡, 成志伟, 何聪芬*. 皮肤屏障结构脂质研究进展-脂质代谢相关酶. 中国皮肤性病学杂志. 2016, (9):964-967.

[27] 王琪, 刘向慧, 贾小凡, 宋丽雅, 贾焱, 何聪芬*. 皮肤脂质成分分析方法研究进展. 日用化学工业. 2014, 44(4):226-230.

[28] 杨曼丽, 周明月, 胡雪情, 陈风, 何聪芬, 贾焱. 化妆品经皮渗透研究进展——评价方法及促渗技术. 2020. 日用化学工业（已接收）.

六 已授权的发明专利

[1] 贾焱，何聪芬，甘瑶，宋丽雅，成志伟，董坤，刘蕾，一种基于皮肤脂质组学制备适用于早晚的仿生护肤组合物的方法，中国，KLPI170925.

[2] 何聪芬，贾焱，崔乐，江彪，宋丽雅，成志伟，董坤，刘蕾，一种基于皮肤脂质组学制备适用于青年男女的仿生护肤组合物的方法，中国，KLPI170924.

[3] 何聪芬，贾焱，江彪，崔乐，樊琳娜，宋丽雅，成志伟，董坤，刘蕾，一种基于皮肤脂质组学制备适用于敏感皮肤的护肤组合物的方法，中国，KLPI170926.

七 奖励荣誉

[1] 2021年获得北京工商大学优秀硕士论文指导教师

[2] 2018年入选北京市属高校青年拔尖人才培育计划。

[2] 2016年获得北京工商大学教育教学成果二等奖。

[3] 2015年获得北京工商大学35岁以下理工类个人科研总分排名前十名。